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Dr. Murugesan Vanangamudi

Dr. Murugesan Vanangamudi

  • Associate Professor
    Institute of Pharmaceutical Research
  • Department

    Pharmaceutical Research
  • Contact Details:

    Email : vmurugesann@gmail.com

    Contact Number :8555984792

  • Qualifications

    • Ph.D from Uttar Pradesh Technical University, Lucknow, 2012
    • M. Pharm (Medicinal and Pharmaceutical Chemistry) from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, 2005
    • B. Pharm from The Tamil Nadu Dr. M.G.R Medical University, Chennai, 2001
    • Intermediate from Board of Higher Secondary Examination Tamil Nadu, 1996
    • Matriculation from Board of Matriculation Examination Tamil Nadu, 1994
  • Ph.D

    Thesis Supervised

  • Awarded/ Completed-

    Working-

  • Postgraduate

    Thesis Supervised

  • Awarded/ Completed-

    Working-

  • Anitha Kuttiappan, Santenna Chenchula, Murugesan Vanangamudi, Shvetank Bhatt, Radhika Chikatipalli, P Shaila Bhanu, Nagaraju Bandaru, Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: Results of In vivo, in vitro, and molecular docking studies. Journal of Ayurveda and Integrative Medicine. 2024 Sep 6;15(5):101036. Impact Factor: 2.4
  • Murugesan Vanangamudi, Monika Kaushik, Prathap Madeswaraguptha, Vijayaraj Surendran and Pawan kumar Gupta. Anticancer Therapy with Proteolysis-targeting Chimeras [PROTACs] Targeting Towards the Tumor-microenvironment: Development, Current State and Prospects. Current Cancer Therapy Reviews, In Press, Available online 14 May, 2024, DOI: 10.2174/0115733947304955240430124514. Impact Factor: 0.8
  • Vanangamudi, Murugesan; Palaniappan, Senthilkumar; Kathiravan, Muthu Kumaradoss; Namasivayam, Vigneshwaran. Strategies in the Design and Development of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) (2023) Viruses, 15 (10), art. no. 1992, Cited 0 times. Impact Factor: 4.7
  • Chauhan, Laxmi K.; Chopra, Jaishri; Vanangamudi, Murugesan; Tripathi, Indra P.; Bhargava, Amit; Goswami, Ajay K.; Baroliya, Prabhat K. Hydroxytriazenes incorporating sulphonamide derivatives: evaluation of antidiabetic, antioxidant, anti-inflammatory activities, and computational study (2023) Molecular Diversity, 27 (1), pp. 223 - 237, Cited 3 times. Impact Factor: 3.8
  • Surendran, Vijayaraj; Palei, Narahari N.; Vanangamudi, Murugesan; Madheswaragupta, Prathap. Systemic Optimization and Validation of RP-HPLC Method for the Estimation of Ritonavir from Hybrid Polymeric Nanoparticles in Rat Plasma (2022) Current Pharmaceutical Analysis, 18 (6), pp. 650 - 662, Cited 2 times. Impact Factor: 0.6
  • Namasivayam, Vigneshwaran; Palaniappan, Senthikumar; Vanangamudi, Murugesan. Repurposing drugs targeting epidemic viruses (2022) Drug Discovery Today, 27 (7), pp. 1874 - 1894, Cited 3 times. Impact Factor: 7.4
  • Karnatak, Manvika; Hassam, Mohammad; Vanangamudi, Murugesan; Sharma, Siddharth; Kumar Yadav, Dinesh; Singh, Chandan; Puri, Sunil K.; Rawat, Varun; Prakash Verma, Ved. Novel naphthyl based 1,2,4-trioxanes: Synthesis and in vivo efficacy in the Plasmodium yoelii nigeriensis in Swiss mice (2021) Bioorganic and Medicinal Chemistry Letters, 51, art. no. 128372, Cited 5 times. Impact Factor: 2.7
  • Vanangamudi, Murugesan; Priya, Gnana Ruba; Engels, Maida. Current and promising multiclass drug regimens and long-acting formulation drugs in HIV therapy (2021) Frontiers in Clinical Drug Research - HIV, 5, pp. 95 - 139, Cited 1 times.
  • Vanangamudi, Murugesan; Nair, Pramod C.; Engels, S. E. Maida; Palaniappan, Senthilkumar; Namasivayam, Vigneshwaran. Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and Their Inhibition (2021) Advances in Experimental Medicine and Biology, 1322, pp. 63 - 95, Cited 5 times. CiteScore: 6.2
  • Vanangamudi, Murugesan; Kurup, Sonali; Namasivayam, Vigneshwaran. Non-nucleoside reverse transcriptase inhibitors (NNRTIs): a brief overview of clinically approved drugs and combination regimens (2020) Current Opinion in Pharmacology, 54, pp. 179 - 187, Cited 22 times. Impact Factor: 4
  • Dayma, Varsha; Chopra, Jaishri; Sharma, Poonam; Dwivedi, Aparna; Tripathi, Indra P.; Bhargava, Amit; Murugesan, Vanangamudi; Goswami, Ajay K.; Baroliya, Prabhat K. Synthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs (2020) Heliyon, 6 (8), art. no. e04787, Cited 11 times. Impact Factor: 4
  • Sharma, Poonam; Dayma, Varsha; Dwivedi, Aparna; Baroliya, Prabhat K.; Tripathi, I.P.; Vanangamudi, Murugesan; Chauhan, R.S.; Goswami, A.K. Synthesis of sulpha drug based hydroxytriazene derivatives: Anti-diabetic, antioxidant, anti-inflammatory activity and their molecular docking studies (2020) Bioorganic Chemistry, 96, art. no. 103642, Cited 16 times. Impact Factor: 5.1
  • Singh, Karanveer; Kuletha, Shruti; Kaur, Baljeet; Kaur, Amandeep; Tripathi, Dinesh K.; Srivastava, Kishore K.; Murugesan, Vanangamudi; Srikala, Rajala; Chaudhary, Amrendra K.; Sinha, Manish. Synthesis, antitubercular activity, molecular modeling and docking studies of novel thiazolidin-4-one linked dinitrobenzamide derivatives (2020) Current Bioactive Compounds, 16 (1), pp. 68 - 75, Cited 1 times. CiteScore: 2.0
  • Malviya, Bhanwar Kumar; Singh, Karandeep; Jaiswal, Pradeep K.; Shukla, Monika; Verma, Ved Prakash; Vanangamudi, Murugesan ; Jassal, Amanpreet Kaur ; Punjabi, Pinki B. ; Sharma, Siddharth. Catalyst- And Solvent-Free Coupling of 2-Methyl Quinazolinones and Isatins: An Environmentally Benign Access of Diastereoselective Schizocommunin Analogues (2019) ACS Omega, 4 (7), pp. 12146 - 12155, Cited 6 times. Impact Factor: 4.1
  • Namasivayam, Vigneshwaran; Vanangamudi, Murugesan; Kramer, Victor G.; Kurup, Sonali; Zhan, Peng; Liu, Xinyong; Kongsted, Jacob; Byrareddy, Siddappa N. The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic (2019) Journal of Medicinal Chemistry, 62 (10), pp. 4851 - 4883, Cited 116 times. Impact Factor: 7.3
  • Poongavanam, Vasanthanathan; Namasivayam, Vigneshwaran; Vanangamudi, Murugesan; Al Shamaileh, Hadi; Veedu, Rakesh N; Kihlberg, Jan; Murugan, N Arul. Integrative approaches in HIV-1 non-nucleoside reverse transcriptase inhibitor design (2018) Wiley Interdisciplinary Reviews: Computational Molecular Science, 8 (1), art. no. e1328, Cited 17 times. Impact Factor: 11.4
  • Vanangamudi, Murugesan; Poongavanam, Vasanthanathan; Namasivayam, Vigneshwaran. HIV-1 non-nucleoside reverse transcriptase inhibitors: SAR and lead optimization using CoMFA and CoMSIA studies (1995-2016) (2017) Current Medicinal Chemistry, 24 (34), pp. 3774 - 3812, Cited 16 times. Impact Factor: 4.1
  • Suryawanshi, Rahul; Jadhav, Sushama; Makwana, Nandini; Desai, Dipen; Chaturbhuj, Devidas; Sonawani, Archana; Idicula-Thomas, Susan; Murugesan, Vanangamudi; Katti, Seturam B.; Tripathy, Srikanth; Paranjape, Ramesh; Kulkarni, Smita. Evaluation of 4-thiazolidinone derivatives as potential reverse transcriptase inhibitors against HIV-1 drug resistant strains (2017) Bioorganic Chemistry, 71, pp. 211 - 218, Cited 33 times. Impact Factor: 5.1
  • Murugesan, Vanangamudi; Makwana, Nandini; Suryawanshi, Rahul; Saxena, Reshu; Tripathi, Rajkamal; Paranjape, Ramesh ; Kulkarni, Smita; Katti, Seturam B. Rational design and synthesis of novel thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors (2014) Bioorganic and Medicinal Chemistry, 22 (12), pp. 3159 - 3170, Cited 36 times. Impact Factor: 3.5
  • Rawal, R.K.; Murugesan, Vanangamudi; Katti, S.B. Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs (2012) Current Medicinal Chemistry, 19 (31), pp. 5364 - 5380, Cited 34 times. Impact Factor: 4.1
  • Murugesan, Vanangamudi; Tiwari, Vinay S.; Saxena, Reshu; Tripathi, Rajkamal; Paranjape, Ramesh; Kulkarni, Smita; Makwana, Nandini; Suryawanshi, Rahul; Katti, Seturam B. Lead optimization at C-2 and N-3 positions of thiazolidin-4-ones as HIV-1 non-nucleoside reverse transcriptase inhibitors (2011) Bioorganic and Medicinal Chemistry, 19 (22), pp. 6919 - 6926, Cited 38 times. Impact Factor: 3.5
  • Murugesan, Vanangamudi; Sethi, Nidhi; Prabhakar, Yenamandra S.; Katti, Seturam B. CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: Active site requirements (2011) Molecular Diversity, 15 (2), pp. 457 - 466, Cited 13 times. Impact Factor: 3.8
  • Goodarzi, Mohammad; Deshpande, Shreekant; Murugesan, Vanangamudi; Katti, Seturam B.; Prabhakar, Yenamandra S. Is feature selection essential for ANN modeling? (2009) QSAR and Combinatorial Science, 28 (11-12), pp. 1487 - 1499, Cited 24 times. Impact Factor: 3.6
  • Murugesan, Vanangamudi; Prabhakar, Yenamandra S.; Katti, Seturam B.  CoMFA and CoMSIA studies on thiazolidin-4-one as anti-HIV-1 agents (2009) Journal of Molecular Graphics and Modelling, 27 (6), pp. 735 - 743, Cited 46 times. Impact Factor: 2.9

M. Pharm Projects Supervised

  • Design of new chemical entity against HIV-1 RNAase enzyme by Auto dock software.
  • Synthesis, characterization and estimation of some thiazolidine-4-one derivatives by using green chemistry method
  • A Validated RP-HPLC method development for the estimation of cefpodoxime and potassium clavulanate in bulk and pharmaceutical formulation
  • Development and validation of stability indicating RP-HPLC method for the estimation of topiramate in bulk and tablet dosage form

Book Chapter Published

  • Monika Kaushik, Prathap Madeswaraguptha, Murugesan Vanangamudi, Vijayaraj Surendran, Navaneetha Krishnan Subramaniyan, Ashok Kumar. Cancer Causing Viruses:  Targeting signaling pathway and mechanism of prebiotics, probiotics and symbiotics to manage metabolic disorders, ISBN: 9781032702414, In press, CRC Press 2024.
  • Monika Kaushik, Himanshu Sharma, Prathap Madeswaraguptha, Venishaa S, Murugesan Vanangamudi. Synbiotic: Potential Role in Hemochromoatosis Management, ISBN: 9781032702414, In press, CRC Press 2024.
  • Three days workshop attended on “Career in intellectual property rights by Turnip innovations and DPIIT IPR Chair, Nalsar University” from 18 Dec 2023 to 20 Dec 2023.
  • Refresher Courses attended on “UGC Approved Short Term Professional Development Programme” held at indira gandhi national open university, New Delhi from 23 February To 03 March, 2023
  • One week e-FDP attended 2022 on "Recent Advances in Pharmaceutical Sciences", organized by the Department of Pharmaceutics in association with IQAC, Geethanjali College of Pharmacy from 04-July-2022 to 09-July-2022 Sponsored by Teja Educational Society.
  • Participated in four days national Workshop on National Symposium cum Workshop on “Recent Trends in Structural Bioinformatics and Computer Aided Drug Design” [SBCADD’2019]  conducted by department of bioinformatics, Alagappa University, Karaikudi during 12th – 15th February, 2019
  • Participated in two days national Conference on Recent trends in phytopharmaceuticals in treating chronic ailments organized by Sree Vidyanikethan college of pharmacy, Tirupati during October, 25 & 26, 2018.
  • Participated in two days national Workshop on Computational methods in drug discovery organized by Department of Pharmacology, JSS College of Pharmacy, Ooty during September 28 & 29, 2018.
  • Participated in faculty development programme on “Best practices in teaching and research” held at Santhiram College of pharmacy, Nandyal on 5th September 2018.
  • Participated in three days national Workshop on Drug Discovery Technology|A molecular Modeling, Simulations & Dynamics Approach conducted by Biodiscovery Group, India in collaboration with Department of Pharmacology JIPMER, Puducherry during 30th November to 02nd  December, 2017.
  • Participated in two days national symposium on Pharmacy Practice and Clinical Pharmacology organized by Department of Pharmacology, SPMCW, Tirupati and SVCP, Tirupati during 24 & 25th November 2017.
  • Participated in one day national symposium on Bioanalytical Method Development: Quality by Design Approach organized by St. James College of Pharm. Sciences, Chalakudy during 10th November 2017.
  • Participated in Five days national 104th Indian science congress conference held at Sri Venkateswara University, Tirupati during Jan 3 - 7, 2017.
  • Participated in three days 23rd ISCB International Conference (ISCBC-2017) Interface of Chemical Biology in Drug Research Organized by Indian Society of Chemists and Biologists & SRM University, Chennai during 8th-10th February, 2017.
  • Research paper presented entitled “'In Silico Exploration of Thiazolidin-4-one derivatives as Potential wild-type and Double Mutant” at 23rd ISCB International Conference (ISCBC-2017) Interface of Chemical Biology in Drug Research Organized by Indian Society of Chemists and Biologists & SRM University, Chennai during 8th-10th February, 2017.
  • Participated in two day national seminar on “Drug discovery and nanobiotechnology: challenges and opportunities (DDNBCO’S 15)” held in Sree Vidyanikethan College of pharmacy, Tirupathi, September 3rd & 4th 2015.
  • Participated in national conference on Natural Product Research - 2014, organized by the Creative Educational Society’s, College of Pharmacy, Kurnool, during 19th to 20th July 2014.
  • Participated in national seminar on Scope and Prospectives in industry – Institution Interaction, organized by the Sree Vidyanikethan College of pharmacy, Tirupathi, 20th to 21th September 2014.
  • Participated in two day national workshop on Analytical Techniques in Research and Analysis (ATRA-2013), organized by the department of chemistry, JNTUA College of engineering, pulivendula, during 27 to 28 December 2013.
  • Participated two day national level faculty development programme on “Imunotechnology” under TEQIP-II held in Sree Vidyanikethan Engineering College, Tirupati on 25th to 26th march 2013.
  • Participated in national Seminar on Advanced Biopharmaceutical Strategies- a regulatory perspective held in Sree Vidyanikethan College of Pharmacy, Tirupati on 13th and 14th July 2012.

Experience

  • Organization: Institute of Pharmaceutical Research, GLA University, Mathura
    Designation:  Associate Professor
    Experience: Since October 2024
  • Organization: Amity Institute of Pharmacy, Amity University, Gwalior, Madhya Pradesh.
    Designation:  Associate Professor
    Experience:  3.5 years
  • Organization: Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh.
    Designation:  Associate Professor
    Experience: 09 years
  • Organization: Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow, UP. Designation:  Research Fellow
    Experience: 5.5 years
  • Organization: Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Lucknow
    Designation:  Lecturer
    Experience:  01 year & 3 months

Fellowships and awards

  • MHRD scholarship/assistantship through GATE score, awarded for the post-graduate program. (Aug 2003 – Aug 2005).
  • CSIR’S JUNIOR RESEARCH FELLOWSHIP (JRF) – GATE, awarded for the Ph.D programme (Jan 2007 – Apr 2012).

Research Projects

  • Received Start Up Young Scientist Research Grant in Life Sciences, File No. YSS/2015/001938, Rs. 25,35,000 /- from DST-SCIENCE & ENGINEERING RESEARCH BOARD for the research project titled “Design and synthesis of hybrid thiazolidin-4-ones as Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI Resistant HIV‑1 Strains” (Duration: 3 years, from March 2016 to March 2019).
  • Research proposal qualified under the Research Promotion Scheme in the academic year of 2020-2021 (fund requested Rs. 24,29,411 /-) for the project titled “Design and Synthesis of a Novel Class of 4-Aminoquinolinyl derivatives as Potent inhibitor chloroquine resistant (K1) and chloroquine-sensitive (3D7) strains of Plasmodium falciparum”
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